Psilocybin Dosage: Safe Guide for Beginners

Psilocybin, found in “magic” mushrooms, has shown promise for treating mental health issues like depression and anxiety¹. It’s important to know the right dosage, especially for those new to it. This guide will cover different dosages, including microdosing and therapeutic use. We’ll look at the benefits and risks to help you make safe choices.

Introduction to Psilocybin

Psilocybin is the main active substance in some mushrooms, known as “magic mushrooms.”² For centuries, indigenous cultures have used these mushrooms for spiritual and healing purposes².

What are Magic Mushrooms?

Magic mushrooms are a type of fungi that naturally make psilocybin². This substance changes into psilocin in the body². Psilocin levels peak about 20-30 minutes after eating them². It stays active for about 3 hours².

Traditional and Indigenous Use

In Mexico and Central/South America, groups like the Nahuatls and Mayans have used these mushrooms for health and understanding sickness². Recently, researchers in the U.S. have started studying psilocybin for mental health issues³.

Psilocin connects with many brain receptors, including those for serotonin and dopamine². It also affects other receptors in the body².

“Psilocybin neuromodulatory effects are correlated with 5-HT2AR occupancy, and it promotes enhanced neuroplasticity, seen as increased resting-state functional connectivity across brain networks, particularly involving the prefrontal cortex.”²

Psilocybin can make brain cells grow and change in healthy ways².

Psilocybin Dosage

Psilocybin, found in “magic mushrooms,” comes in different dosages, from tiny amounts to full therapeutic levels. Knowing the right dosage is key for safe and effective use. This is true whether you’re exploring on your own or looking for health benefits.

Microdosing Psilocybin

Microdosing means taking a tiny bit, usually 10-20% of what’s needed for a full trip⁴. The aim is to get some cognitive and emotional boosts without the full-on trip. A microdose is about 0.1 – 0.2 grams⁴.

Therapeutic Psilocybin Dosage

In medical settings, psilocybin is given in stronger doses to help with depression and anxiety⁵. These doses can lead to deep psychedelic experiences that might improve mental health for a long time⁵. The dosage depends on the mushroom’s strength, type, and what part you use, usually between 1.0 – 2.5 grams⁴.

Research shows that giving 20 to 30 mg of psilocybin per 70 kg of body weight is safe for many people at once⁶. This shows psilocybin can be safely given to people, which is important for treating serious mental health issues like depression and PTSD⁶.

Remember, the right dosage and how to take psilocybin should always be checked with a healthcare professional. They’ll consider your unique situation and what you’re trying to achieve.

“The analyzed data included a wide range of body weights from 49 to 113 kg, showing no evidence that body weight influenced the subjective effects of psilocybin.”⁵

Short-Term Effects of Psilocybin

Psilocybin, found in over 100 mushroom species, changes the mind and body quickly⁷. These effects start within 15-45 minutes and can last hours.

Users may feel more emotions, see things differently, and time can seem to slow down or speed up⁷. The effects depend on the dose, with higher doses causing deeper and sometimes scary experiences⁷.

Psilocybin can make your heart race, raise blood pressure, and cause nausea⁷. You might feel weak, have a change in body temperature, and struggle with coordination and judgment⁷.

Most psilocybin use is safe in a controlled setting, but some people have bad trips with anxiety, fear, and paranoia⁷. These bad experiences can be scary and might lead to ongoing mental health issues⁷.

Research shows psilocybin can have both good and bad effects on mental health⁸. A study found stress and anxiety levels went down after using psilocybin, but then went back to normal a month later⁸.

The effects of psilocybin can be different for everyone, depending on the dose, your body, and the setting⁷. It’s important to be careful and use it with guidance from experts to avoid risks and get the most benefit⁷.

Psilocybin’s effects can change a lot from person to person, based on the dose and setting⁷. Some have great experiences, while others may feel anxious, panicked, or even psychotic⁷.

“Psilocybin can produce profoundly unpleasant experiences at high doses, and there are risks associated with mushrooms, including impaired judgment, anxiety or panic attacks, bad trips, poisoning, and death from consuming the wrong type of mushroom.”⁷

Using psilocybin responsibly is key⁷. Knowing the effects and risks helps people make smart choices and get advice from experts for a safe and meaningful experience⁷.

Potential Benefits of Psilocybin

Research is showing that psilocybin, a compound in some mushrooms, could help with mental health issues⁹. It seems to help people with hard-to-treat depression, obsessive-compulsive disorder, and cancer patients’ fear and anxiety⁹.

Psilocybin for Depression

A study at Johns Hopkins Medicine found that psilocybin with talk therapy helped with depression⁹. Some people felt better for up to a year after just two treatments⁹. It also helps increase brain flexibility, which is good for those with depression⁹.

Psilocybin for Anxiety Disorders

Psilocybin has shown promise in helping people quit smoking and treat anorexia nervosa, leading to more research in the U.S⁹. It can also make people more open-minded, creative, and caring⁹.

More studies are needed, but early results suggest psilocybin-assisted therapy could be a big step forward for mental health⁹.

Research over the last 20 years shows psilocybin could be a game-changer for mental health⁹.

“Psilocybin therapy has been found beneficial in relieving symptoms of treatment-resistant depression, obsessive-compulsive disorder, and easing fear and anxiety in individuals with terminal cancer.”

But, using psilocybin outside of a controlled setting is risky and illegal⁹.

Potential Risks of Psilocybin

Psilocybin, found in “magic mushrooms,” has shown promise for therapy¹⁰. But, it’s not risk-free¹⁰. Physical side effects can include nausea, vomiting, headaches, and more¹⁰. You might also feel anxiety, fear, or isolated thoughts¹⁰. These effects depend on the dose and setting.

Physical Side Effects

Psilocybin can cause physical effects, some of which are concerning¹¹. You might feel numb, have a fast heart rate, or weak muscles¹¹. Rarely, it can lead to serious issues like muscle damage or kidney failure¹⁰. People with heart problems could be at higher risk due to its effects on heart rate and blood pressure¹².

Psychological Side Effects

Psilocybin’s effects on the mind can be deep¹¹. You might feel more emotions, become paranoid, or lose your sense of reality¹¹. In some cases, it can cause flashbacks that last for a long time¹¹. Regular use can make it hard to adjust back to everyday life¹¹. If you’re prone to mental health issues, psilocybin could be more dangerous¹².

Psilocybin has shown promise in studies¹². But, there are no approved products with psilocybin in Canada or other places¹². It’s key to screen and assess risks to see who might benefit or be at risk from it¹⁰.

“The use of psilocybin with other substances like cannabis or alcohol may elevate the risks of adverse effects.”¹²

Psilocybin Sources and Safety

Psilocybin, found in psychedelic mushrooms, comes from various species, with Psilocybe cubensis being the top source¹³. But, the amount of psilocybin and its breakdown product psilocin can change a lot, making it hard to know the right dose¹³. In studies, scientists use made psilocybin, but most people use the real mushroom kind¹⁴.

There are ways to check the psilocybin in mushrooms and look for harmful stuff, which is key for safety¹³. Now, more people in the U.S., about 8 million adults, have tried psilocybin mushrooms in the last year¹³. It’s more popular than other drugs like MDMA and LSD¹³.

Mushroom Species and Potency

The amount of psilocybin in magic mushrooms can be quite different, from 0.1% to 2% by weight¹⁵. For example, 3.5 grams might have 35 mg of psilocybin, which is a strong dose¹⁵. Some people take a smaller dose, around 100 mg to 250 mg, for microdosing¹⁵.

Interest in microdosing psilocybin has grown a lot since 2015, with many trying it for fun or mental health¹³. Oregon and Colorado are leading in this trend, as they’ve made it easier to use these mushrooms¹³. But, we need more studies to know if it’s safe and works well¹³.

More people are finding psilocybin, leading to more drug busts¹³. A survey found people use it for fun, mental health, and personal growth¹³.

“Psilocybin was safely given in doses of 10mg or 25mg to up to six people at once in the study.”¹⁴

A study tested psilocybin on 89 healthy people, giving some 10mg or 25mg, and others a fake pill¹⁴. They watched these people for a few hours and checked in with them for 12 weeks. No one stopped because of bad reactions to the drug¹⁴.

The next step in this study is to see if psilocybin helps with depression and PTSD¹⁴. They plan to start this part in 2022¹⁴.

Legality and Access to Psilocybin

In Canada, psilocybin is illegal to make, sell, and have. But, there are legal ways to get it for health reasons¹⁶. This change shows how the rules on psilocybin are changing¹⁷.

Clinical Trials and Legal Access

Canada has approved 36 studies on psilocybin¹⁸. These studies look at how it can help with depression and PTSD¹⁸. There’s also a program that lets doctors get psilocybin for their patients¹⁷.

So far, 176 Canadians can use psilocybin through this program¹⁸. Doctors need a license to get it, and they must report any bad reactions quickly¹⁷.

A Canadian company, Filament Health, can make three types of psilocybin capsules¹⁸. Health Canada also made a rule to allow more use of psilocybin and MDMA¹⁷.

People want more research on psilocybin for mental health, especially for veterans with PTSD¹⁸. Health Canada wants more money for studies on using psilocybin therapy for these veterans¹⁸.

“Psilocybin and MDMA are the most frequently used psychedelic drugs in psychedelic-assisted psychotherapy.”¹⁷

Screening and Risk Assessment

When looking into psilocybin-assisted therapy, it’s key to screen and assess risks to find who will benefit or be at risk¹⁹. We use established methods to keep out those at high risk, but we need more tools for psilocybin¹⁹. Researchers aim to create better ways to predict how people will react to psilocybin, ensuring it’s given safely¹⁹.

Things like a person’s traits, health history, and where they take psilocybin affect the risks and benefits¹⁹. It’s vital to talk to health experts who know about psilocybin therapy to see if it’s right for you and plan your treatment¹⁹.

Health Canada sees the growing interest in using psychedelics for therapy, knowing there are risks for those in clinical trials¹⁹. In Canada, MDMA and psilocybin are often used in trials, making people feel happy, outgoing, and more connected¹⁹. Psilocybin can change moods, make you see things differently, and change how you see time¹⁹.

For safe use of psilocybin, therapists should be trained and licensed, with at least two there during the session¹⁹. A doctor must oversee the trial and be ready to help, and the place should be calm to lessen risks¹⁹. After therapy, checking in with mental health professionals is important, and any big problems must be reported to Health Canada¹⁹.

Before starting psilocybin therapy, you must understand the risks, both physical and mental¹⁹. Making sure products are made safely is crucial, and Health Canada checks to make sure trials and products follow the rules¹⁹.

Psilocybin has a long history, used for thousands of years in many cultures²⁰. Albert Hofman isolated it in 1958, the same year he made LSD²⁰. Studies show it can help with addiction, depression, and mood at the end of life, giving hope to many²⁰.

A big study looked at 436 people, finding psilocybin really helped with depression, especially for those with secondary depression²¹. Being older or having tried psychedelics before seemed to help more with symptoms²¹.

“Psilocybin has shown promise in the treatment of addiction, particularly in small, open-label trials focusing on nicotine and alcohol, with a low toxicity and low risk of overuse.”²⁰

As psilocybin therapy grows, making sure we screen and assess risks well is key. Working with health experts and following safety steps helps people safely try this new therapy.

Conclusion

This guide has shown that psilocybin, found in “magic” mushrooms, could help with mental health issues like depression, anxiety, and addiction⁵. But, using psilocybin safely and effectively means knowing the right dosage, its benefits, and risks.

We looked at the various psilocybin dosages, from microdosing to therapeutic use. We also talked about the immediate effects, benefits, and risks of taking psilocybin⁵²². The article also covered the legality and accessibility of psilocybin. It stressed the need for advice from healthcare pros in psilocybin-assisted therapy.

As studies show more about psilocybin’s therapeutic potential, it’s key to use it with caution, responsibility, and care for your health and safety⁵²²²³. Knowing about psilocybin dosage, safety, and therapeutic use helps people make smart choices. This way, they can try this amazing compound responsibly.

Source Links

1. PDF
2. Psilocybin – an overview | ScienceDirect Topics
3. Psilocybin in neuropsychiatry: a review of its pharmacology, safety, and efficacy | CNS Spectrums | Cambridge Core
4. mushrooms_onesheet
5. Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches
6. Psilocybin, in 10mg or 25mg doses, has no detrimental effects in healthy people
7. Effects of Psilocybin Mushrooms | Hallucinogenic Shrooms
8. Emotions and brain function are altered up to one month after a single high dose of psilocybin – Scientific Reports
9. “Magic Mushrooms,” Psilocybin and Mental Health
10. PSILOCYBIN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
11. Psilocybin and magic mushrooms
12. Psilocybin and psilocin (Magic mushrooms)
13. Microdosing and tripping on mushrooms is on the rise in U.S.
14. Study Identifies Safe Dosage Regimen for Psilocybin
15. Magic Mushroom Dosing Guide: Finding Your Ideal Dose
16. Legal status of psilocybin mushrooms
17. Notice to stakeholders: Requests to the Special Access Program (SAP) involving psychedelic-assisted psychotherapy
18. Canadians can ask for legally produced medicinal psilocybin. Getting it isn’t always easy
19. Notice to stakeholders: Health Canada’s expectations regarding risk-management measures for clinical trials involving psychedelic-assisted psychotherapy
20. Analysis of Psilocybin-Assisted Therapy in Medicine: A Narrative Review
21. Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis
22. Johns Hopkins study finds Psilocybin dosage ‘sweet spot’ for positive and lasting effects
23. Psilocybin – an overview | ScienceDirect Topics